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Background: This study examined the relationship between the empowerment, and occupational professionalism of physical therapists, and the factors affecting their job satisfaction. Methods: The subjects of the study were 240 physical therapists who had worked at medical institutions for more than a year. Data were collected from April 1 to 30, 2022. Results: The mean scores for job satisfaction, empowerment, and occupational professionalism were 3.43±.52, 3.60±.60, and 3.74±.40 points, respectively. Empowerment was positively correlated with occupational professionalism (r=.75, p<.001) and job satisfaction (r=.59, p<.001). Also, occupational professionalism was positively correlated with job satisfaction (r=.68, p<.001). The factors influencing job satisfaction were empowerment (β=.17, p<.05) and occupational professionalism (β =.56, p<.001), showing an explanatory power of 48%. Conclusions: The results of this study revealed that the higher the empowerment and occupational professionalism, the higher the job satisfaction of physical therapists. To improve their job satisfaction, it is, therefore, necessary to develop and apply an effective program to improve their empowerment and occupational professionalism level. These research results can be useful as basic data for improving the job environment of these therapists and the policies relating to their work.