원문정보
초록
영어
Hericium erinaceus (lion’s mane mushroom) is an edible and medicinal mushroom that belongs to the family Hericiaceae. It has been traditionally used for the treatment of memory impairment and gastrointestinal diseases. We previously reported hericene A as an anti-diabetic constituent of H. erinaceus and investigated the effect of cultivation substrates on its content. As the continuation, the contents of five major compounds, including hericenes A-D, which exhibit α-glucosidase inhibitory activity together with ergosterol, were investigated according to the cultivation stage. H. erinaceus was cultured for 5 stages to induce fruiting bodies, and the contents of the compounds at each stage were quantified through HPLC analysis. Among the major compounds the content of hericene A was the highest, followed by hericene C and the content of hericenes B and D was relatively low. The contents of four hericene derivatives are the highest at stage 4 whereas the content of ergosterol was highest at stage 5. The highest α-glucosidase inhibitory activity of H. erinaceus was at stage 4, which correlates with the contents of hericene derivatives. Conclusively, H. erinaceus with better efficacy and high content of active constituents can be secured by the optimization of cultivation conditions.