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Original Article

Whole body vibration accelerates the functional recovery of motor nerve components in sciatic nerve-crush injury model rats

원문정보

Atsushi Doi, Kyoka Oda, Masaki Matsumoto, Honoka Sakoguchi, Mizuki Honda, Yuma Ogata, Asuka Nakano, Misato Taniguchi, Shunya Fukushima, Kyogo Imayoshi, Kanta Nagao, Masami Toyoda, Hiroki Kameyama, Motoki Sonohata, Min-Chul Shin

한국운동재활학회 JER Vol.19 No.3 2023.06 pp.149-162
피인용수 : 0건 (자료제공 : 네이버학술정보)

초록

영어

This study aimed to investigate the effect of whole body vibration (WBV) on the sensory and motor nerve components with sciatic nerve injury model rats. Surgery was performed on 21 female Wister rats (6–8 weeks) under intraperitoneal anesthesia. The nerve-crush injuries for the left sciatic nerve were inflicted using a Sugita aneurysm clip. The sciatic nerve model rats were randomly divided into two groups (n=9; control group, n=12; WBV group). The rats in the WBV group walked in the cage with a vibratory stimulus (frequency 50 Hz, 20 min/day, 5 times/wk), while those in the control group walked in the cage without any vibrato-ry stimulus. We used heat stimulation-induced sensory threshold and lumbar magnetic stimulation-induced motor-evoked potentials (MEPs) to measure the sensory and motor nerve components, respectively. Further, morphological measurements, bilateral hind-limb dimension, bilateral gastrocnemius dimension, and weight were evaluated. Conse-quently, there were no significant differences in the sensory threshold at the injury side between the control and WBV groups. However, at 4 and 6 weeks postoperatively, MEPs latencies in the WBV group were significantly shorter than those in the control group. Furthermore, both sides of the hind-limb dimension at 6 weeks postoperatively, the left side of the gastrocnemius dimension, and both sides of the gastrocne-mius weight significantly increased. In conclusion, WBV especially ac-celerates the functional recovery of motor nerve components in sciatic nerve-crush injury model rats.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Animals and surgery
Measurement of the sensory threshold with heat stimulus
Measurement of LMS-induced MEPs
Analysis of LMS-induced MEPs
Measurement of hind-limb dimension, weight of the gastrocnemius muscle, and gastrocnemius dimension
WBV and experimental protocol
Statistical analysis
RESULTS
The effects of WBV on heat-stimulation-induced sensory threshold
The effects of WBV for both LMS-induced MEPs amplitude and latency at 2 weeks postoperatively
The effects of WBV for both MEPs amplitudes and latencies at 4 weeks postoperatively
The effects of WBV for both MEPs amplitudes and latencies at 6 weeks postoperatively
The effects of WBV for both MEPs amplitudes and latencies at 8 weeks postoperatively
The effects of WBV for bilateral hind-limb dimension
The effects of WBV for both dimension and weight of gastrocnemius muscle
DISCUSSION
Whole body vibration and sensory effects
Whole body vibration and motor nerve effects
Whole body vibration and morphological effects
Research limitation
Clinical application
SUPPLEMENTARY MATERIALS
CONFLICT OF INTEREST
ACKNOWLEDGMENT
REFERENCES
Supplementary Materials

키워드

저자정보

  • Atsushi Doi Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan, Division of Health Sciences, Graduate School of Health Sciences, Kumamoto Health Science University, Kumamoto, Japan
  • Kyoka Oda Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Masaki Matsumoto Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Honoka Sakoguchi Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Mizuki Honda Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Yuma Ogata Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Asuka Nakano Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Misato Taniguchi Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Shunya Fukushima Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Kyogo Imayoshi Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Kanta Nagao Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Masami Toyoda Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Hiroki Kameyama Department of Medical Technology, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan
  • Motoki Sonohata Department of Orthopaedic Surgery, Saga Central Hospital, Saga, Japan
  • Min-Chul Shin Department of Rehabilitation, Faculty of Health, Kumamoto Health Science University, Kumamoto, Japan, Division of Health Sciences, Graduate School of Health Sciences, Kumamoto Health Science University, Kumamoto, Japan

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