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The purpose of this study is to find out the herb-pair combination and basic herbal formula composed of Cannabis Semen (⿇仁) written in ‘Sheng ji zong lu (聖濟總錄).’ To search for herb-pair combination and basic herbal formula of Cannabis Semen (⿇仁), we analyzed the fifteen most frequently mentioned major indication symptoms of Cannabis Semen in Sheng ji zong lu, the Chinese classical medical literature. Among the associated herbal formulae for treating major indication symptoms, if there is a high-frequency drug pair, we set it as a herb-pair, and when herb-pair have constituted a herbal formula, we set it as a basic herbal formula. We have found three basic herbal formulas including Cannabis Semen for treating major indication symptoms. We have found six herb-pairs including Cannabis Semen for treating major indication symptoms. In some major indication symptoms, we could not find any herb-pairs or basic herbal formulas including Cannabis Semen. Basic herbal formulas composed of Cannabis Semen are Maindaihuang-huan (Marendahuang-wan, ⿇仁⼤⿈丸) and Yunjang-huan (Runchang-wan, 潤腸丸), which treat constipation, Maindaihuang-huan (Marendahuang-wan, ⿇仁⼤⿈丸) which treats flaccidity of lower limbs, and Gamcho-san (Gancao-san, ⽢草散) which treats diseases related to child delivery. Cannabis Semen forms herb-pair and the basic herbal formula with the following herbs: Rhei Rhizoma (⼤⿈), Ginseng Radix (⼈蔘), Aurantii Fructus Immaturus (枳殼), Saposhnikoviae Radix (防⾵), Saigae Tataricae Cornu (羚⽺⾓), Gardeniae Fructus (梔⼦仁), Atractylodis Rhizoma Alba (⽩朮).