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Recently, International Organizations including World Economic Forum and ICAO warn that possibility of a outbreak of terrorism in a way of Chemical, Biological, Radiological, Nuclear as Weapons of Mass Destruction in the result of the global threat assessment analysis. Due to the learning effect of COVID-19 pandemic such as spreading virus extensively, high fatality rate, economic ripple effect, social turmoil et cet around the globe, the way of terrorism could change to CBRN which is easy to acquirement of the material or agent and huge damaging effect to human with just a small amount. Between 1970 and 2016 there were a total of 348 chemical, 13 radiological and 36 biological attacks such as Anthrax Spores, Novichok Nerve Agents, Sarin Gas, VX Nerve Gas, Ricin Toxin in USA, England, Japan, Malaysia and France and Germany respectively. To response to the potential threat, Republic of Korea have to prepare, review and carry out national and airport contingency plan in terms of full-time CBRN exercise, prepare the dedicated HVAC facilities and train the airport staff to recognize and report coule-be infective CBRN terrorism.