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Purpose: This study was conducted to provide basic data for a health promotion program by analyzing the effects of high school students’ mental health-related factors on oral symptom experiences. Methods: This study included 24,833 high school students who participated in the screening and health survey in the “17th (2021) Adolescent Health Behavior Survey.” SPSS software (SPSS Statistics ver. 21.0; IBM) was used for statistical analysis. Multiple sample logistic regression analysis was performed. The significance level was set to 0.05. Results: The result of the analysis on the effect of mental health revealed that oral symptom experience was low in students without depression and suicidal thoughts. Oral symptom experience was high in students with stress perception. Additionally, the experience of oral symptoms was low when there was sufficient subjective sleep. Conclusion: Therefore, it is necessary to develop a customized oral health education program for early detection of oral symptoms and oral health promotion in high school students. Furthermore, it suggests the need for strategies and continuous oral health guidance to practice proper oral health habits to maintain healthy oral conditions.