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Purpose: The purpose of this study was to investigate the factors influencing performance of the clinical nurses about the management of nosocomial infection. Method: The data were collected using structured questionnaire from 300 clinical nurses from April 26, 2004 to May 20, 2004. The data analyzed by the SPSS (ver10.0)program, and it included descriptive statistics, t-test, ANOVA, the Pearson correlation coefficient, stepwise multiple regression. Result: Personal hygiene management and disinfection equipment management had the higher record than other dimensions. The level of recognition for management of nosocomial infection showed positive correlation with the level of performance for management of nosocomial infection. The level of recognition for management of nosocomial infection, working period, number of hand washing, have significant effects on the degree of a performance for management of nosocomial infection. These predictive variables of the degree of a performance for management of nosocomial infection explained 17% of variance. Conclusion: It is needed to be developed for the effective management of nosocomial infection through the educational program.