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Purpose: This study was conducted to identify factors influencing musculoskeletal problems in construction workers over the age of 50. Method: This study used the data of 1,032 raw data from the 6th Working Environment Survey of the Occupational Safety and Health Corporation as the analysis subject. The investigation period was from October 2020 to April 2021. The data were analyzed using SPSS/WIN 23.0 by conducting frequency analysis, chi-square test and logistic regression. Result: Factors affecting the musculoskeletal problems of construction workers over 50 years of age were academic level(p=.006) in general characteristics, uncomfortable posture (p=.001) and handling of heavy objects(p=.014) in work-related characteristics, In health-related characteristics, sleep disturbance(p<.001) and experience of fatigue(p<.001) were found. Conclusion: In order to manage musculoskeletal disorders of workers aged 50 and over, it is necessary to prepare an ergonomic working environment, to provide a break during work, and to manage the health of workers by countermeasures against fatigue and sleep management in the construction industry.