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Purpose: This study aims to analyze the effects of flipped learning on paramedic students’ self-directed learning and academic self-efficacy. Methods: A one-group pretest, posttest design was utilized for the 32 paramedic students who participated. The data were analyzed by employing paired t-test and Pearson correlation coefficient along with the SPSS 23.0 program. Results: The scores of self-directed learning and academic self-efficacy significantly increased after flipped learning classes (t = -3.90, p<.05; t = -5.92, p<.05, respectively). Conclusion: Flipped learning is an effective intervention for improving self-directed learning and academic self-efficacy in paramedic education. In the long run, the application of flipped learning will play a role in improving the paramedic students’ educational environment and strengthening the overall abilities of students.