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Objectives: The purpose of this study is to identify the life satisfaction of women with disabilities and the factors affecting their life satisfaction to improve their quality of life. Methods: This study used secondary data, the 2020 Survey of the Disabled. The subjects were 2,725 women with disabilities aged 20 or older who responded to the survey. The SPSS Windows 26.0 program was used for data analysis. Technology analysis, chi-test, and multi-logistic analysis were performed to identify the factors affecting the life satisfaction of women with disabilities. Results: Age, education level, marital status, type of medical insurance type, subjective economic status, disability severity, subjective health status, health screening, chronic disease, stress, depression, suicidal ideation, and variables that can go out alone. As a result of multi-logistic regression analysis on factors affecting life satisfaction of women with disabilities, it was analyzed that education level, marital status, subjective economic status, subjective health status, health screening, chronic disease, stress cognitive status, depression, suicide ideation, and variables that can go out alone had a statistically significant effect. Conclusion: Based on the analysis results of this study, it is required to develop and operate health education and health promotion programs for physical and mental health management of women with disabilities.