earticle

영어

Malignant melanoma is highly resistant to conventional treatments and is one of the most aggressive types of skin cancer. Conventional cancer treatments are limited due to drug resistance, tumor selectivity, and toxicities. Therefore, new treatments with fewer side effects and excellent effects should be developed. A ganglioside, a molecule composed of a glycosphingolipid, has crucial roles involved in cell-cell interaction, cell growth, proliferation, inflammation, differentiation, and tumorigenesis. Meanwhile, Quercetin (Qu) is considered that potentially inhibit cancer growth, proliferation, invasion, and metastasis, the relationship between its effects on malignant melanoma and ganglioside expression has not been clear. The aim of this study was to investigate the anti-cancer effects of Qu based on the relationship between protein structure and ganglioside on human skin cancer. In this study, quercetin, a flavonoid drug, did not induce toxicity in the human epithelial cell line HaCaT, but Its was abnormal cell elongation and morphological change in the proliferation and growth of skin cancer. Moreover, Its was treated so that cells in the G1/G0 phase cannot proceed to the subsequent S phase, which induces cell cycle arrest. The proliferation rate of cell migration was a certain range of proliferation was inhibited, it can be strongly assumed that this result is directly related to the expression of the various proteins analyzed above. Additionally, we discovered ganglioside decreased in melanoma with quercetin treatment. Taken together, it will be important evidence and present their potential as future therapeutic agents for treating carcinogenesis to figure out the molecular relationship between quercetin, ganglioside, and an anti-target protein of melanoma.