원문정보
초록
영어
Glycans, also known as carbohydrates, saccharides, or simply as sugars, play central roles in many biological processes and have useful properties in a variety of applications from biomarker discovery to therapeutics. However, glycans have received little attention from the research community due to the lack of tools to probe their often complex structures and properties. Recently, advances in glycomic and glycoproteomic methods along with the development of technology in mass spectrometry allow us to better understand the role of the glycome in biological processes in areas as broad as biotherapeutics, infection, brain, and cancer. The challenges are no longer scientific but technical. In this lecture, we will cover the glycomic methods that enables in-depth structural characterization of sugar chains and the glycoproteomic methods for obtaining comprehensive site-specific glycosylation information using mass spectrometry-based platforms. In addition, glyco-informatics and database that automate interpretation of glycome data, which are key to the broader implementation of glycoscience, will be discussed.