earticle

영어

As clinical trials on acne, this study aimed to assess the potential of citral in easing acne inflammation by inhibiting and unveiling the inflammatory activity of citral. For this, a total of 36 testees with high acne occurrence (age 19-23) were chosen and administered citral (0.5%, 1%) twice a day over 12 weeks. Then, the size and severity of inflammatory acne and amount of sebum production were investigated. In addition, inflammation images were analyzed. According to clinical trials, inflammation improvements were confirmed in all experimental groups (both 0.5% and 1% citral contents) (p＜0.05). When the size and shape of a pustule, which are critical indicators for in inflammation improvements, were observed, in particular, both size and shape diminished by 52% in the 1% citral group (p＜0.05). In terms of sebum production, T-zone revealed a significant decrease in the 1% citral group (p＜0.05) while U-zone showed a decrease in the 0.5% citral group (p＜0.05). According to analysis of inflammation images, considerable inflammation improvements were found in both 0.5% and 1% citral groups. After inflammation, pigmentation also improved, resulting in skin brightening. The above results confirm that citral is more effective in easing mild acne symptoms. In terms of inflammation improvements, it appears that the 1% citral group is more effective.

중국어

本研究作为粉刺皮肤疾病的人体试验研究，旨在验证柠檬草油主成分柠檬醛抑制炎症活性的功效，并确认柠檬醛是否具有改善粉刺皮肤炎症的功效。试验方法采用的是人体试验。为此，选定粉刺发生频度高的36名19-23岁受试对象，在12周期间每天使用2次柠檬醛(含量为0.5%, 1%)试验物质，用来观察确认发炎性粉刺大小及发炎情况、皮脂分泌量、炎症照片等。人体试验结果显示，0.5%和1%含量的柠檬醛试验组的粉刺皮肤炎症都得到了改善(p＜0.05)。尤其，重点观察改善炎症的重要指标，即脓疱的大小和形态，发现在1%含量的柠檬醛试验组中，粉刺大小和形态相比原来缩小了52%(p＜0.05)。观察皮质分泌减少情况，发现T-ZONE的皮质分泌在1%含量的柠檬醛试验组中明显减少(p＜0.05)，而U-zone的皮脂则在0.5%含量的柠檬醛试验组显著减少(p＜0.05)。观察炎症照片，在0.5%和1%含量的柠檬醛试验组中都发现炎症得到显著改善，而且还看到炎症引发的色素沉淀也得到改善，肤色也渐渐好转。这样的结果证实了柠檬醛作为外用药剂，对于轻度粉刺更有效。在改善炎症方面，1%含量的柠檬醛试验组的改善效果更加显著，因此今后可用于改善炎症的原料。