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Original Article

SGLT2 저해제/metformin 고정용량복합제의 국내 사용 현황

원문정보

Use of SGLT2 inhibitor/metformin fixed dose combination in Korea

최하은, 이지원, 제남경, 정경혜

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Background: The use of combination therapy and fixed-dose combination therapy is increasing for the treatment of type 2 diabetes. Sodium glucose cotransporter-2 inhibitor (SGLT2i) is a drug class used in combination with metformin. Methods: Type 2 diabetes patients on SGLT2i/metformin combination therapy were extracted from the 2019 Health Insurance Review & Assessment Service- National Patients Sample. On July 1, 2019, SGLT2i and metformin fixed-dose combination (SGLT2i/metformin FDC) and two-pill combination (TPC) groups were identified, and a chi-square test and multiple logistic regression were performed. Results: Of total 2,992 patients, 1,077 (36%) were prescribed SGLT2i/metformin FDC and 1,915 (64%) were prescribed TPC. We found that the most common comorbidities were in the order of dyslipidemia, gastrointestinal disease, and hypertension. Multiple logistic regression analysis showed that the use of SGLT2i/metformin FDC was lower than TPC in patients with diabetic neuropathy (OR=0.76, p=0.008). Clinic (OR=2.09, p<0.001) and general hospital (OR=1.40, p=0.019) showed higher tendency to prescribe SGLT2i/metformin FDC compared to tertiary hospital. The tendency of prescribing SGLT2i/metformin FDC was lower in Kyeonggi (OR=0.79, p=0.037), Gyeongsang (OR=0.77, p=0.025) and Chungcheong (OR=0.68, p=0.007) than Seoul. Conclusion: Factors related to the use of SGLT2i/metformin FDC in patients with type 2 diabetes were complication, medical institution and region. The tendency to prescribe SGLT2i/metformin FDC was relatively higher in clinics than in tertiary general hospitals and in Seoul than in other regions.

목차

ABSTRACT
연구 방법
연구자료
연구대상과 자료수집방법
연구변수
자료분석방법
연구 결과
연구대상자 분석
SGLT2i/metformin FDC 또는 TPC
SGLT2i/metformin FDC 사용에 영향을 미치는 인자
고찰
결론
참고문헌

저자정보

  • 최하은 Ha Eun Choi. 중앙대학교 약학대학
  • 이지원 Ji Won Lee. 중앙대학교 약학대학
  • 제남경 Nam Kyung Je. 부산대학교 약학대학
  • 정경혜 Kyeong Hye Jeong. 중앙대학교 약학대학

참고문헌

자료제공 : 네이버학술정보

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