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Purpose: The purpose of this study was to identify the experiences of depression, suicidal thoughts, and habitual drug use in middle and high school students and examine their relationship with the oral symptoms experiences. Methods: The participants of this study were 54,948 middle and high school students who took the screening and health survey at the 16th “Youth Health Behavior Survey” (2020). The SPSS statistical software (IBM SPSS 23.0 for Windows; IBM) was used for data analysis. The significance level was set to 0.05. Results: Complex-sample logistic regression analysis was performed to confirm the relationship between the experiences of depression, suicidal thoughts, and habitual drug use and oral symptom experienced. The results indicated that the absence of depression, suicidal thoughts, or habitual drugs had a significant effect on oral symptom experience. Conclusion: A systematic counseling program for early detection of oral symptoms and oral health promotion as well as strategies for practicing correct oral hygiene are required. Additionally, it is necessary to develop a customized education program to promote health education in middle and high school students. It can be used as the basis for an integrated support system that students can use to grow healthy. A differentiated program on the topic of mental health promotion for each grade can be planned and its effects can be monitored.