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Background: In this study, the Capstone Design was applied to the clinical dental hygiene course of the Department of Dental Hygiene, and its effect was confirmed by qualitatively evaluating the students’ reflection on the capstone design class experience. Methods: This study was conducted for the “Clinical Dental Hygiene and Practice Ⅲ” course, in which third year students develop the ability to judge and plan dental hygiene based on problem-solving ability and critical thinking. By applying the Capstone Design within the core curriculum of the class, the students analyzed problems based on their major knowledge of dental hygiene in order to improve their ability to manipulate periodontal instruments, and focusedon the process of developing the contents of periodontal instruments by using them. Results: The application of Capstone Design on clinical dental hygiene and practice Ⅲ classes increased students' active class participation, and through the problem-solving process, students' learning and confidence improved. Conclusion: The Capstone Design can be viewed as a teaching method that promotes the participation of students in the dental hygiene department and can effectively help their learning and confidence through a problem-solving process.