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Purpose: The present study aimed to develop rehabilitation programs for patients with musculoskeletal disorders by using marine resources. Methods: Domestic and international papers from the past 20 years published between January 2000 - October 2021 were selected, and only studies that included participants with musculoskeletal disorders were considered for the investigation. In detail, the clinical question of the study was analyzed through PICO (Participants, Interventions, Comparisons, Outcomes) criteria. The screening of the articles was conducted by 4 researchers majoring in rehabilitation science by using the following search engines and databases: Google Scholar, Pubmed, Science Direct, and Scopus. The searched terms were “marine healing”, “marine healing resources”, “musculoskeletal”, “rehabilitation”, and “rehabilitation program”. Among the collected studies, duplicate papers and papers with unclear subject characteristics were excluded and the remaining studies were analyzed after determining suitability through a screening process. Results: A total of 17 articles were systematized, analyzed, and classified. Among the selected articles, the marine resources used were: mud (13), sea sand (3), and seawater (1). All articles were profoundly reviewed and their content was classified by the PICO format for the development of the marine programs. Conclusion: Three marine programs for patients with musculoskeletal disorders were developed based on the findings of the studied papers, with an emphasis on pain release and motor function improvement of the neck, hand, low back, and feet. These programs were designed to serve as a framework for the future management of national maritime resources.