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Objectives: The goal of this research was to verify the mediating effect of mattering between academic stress of nursing students and their quality of life. Methods: A questionnaire survey was conducted on 147 nursing students in college located in B city from July 13 to July 31, 2020. Data were analyzed by descriptive analysis, t-test, one-way ANOVA, Pearson correlation coefficient and a three-step regression analysis using Baron and Kenny’s method for mediation with the SPSS/WIN 23.0 program. Results: The average score of academic stress, mattering and quality of life were 2.81, 3.75, and 3.69. There was negative correlation between academic stress, mattering and quality of life. Also there was positive correlation between mattering and quality of life. mattering had a partial mediating effect on the relationship between academic stress and quality of life. Conclusions: To improve quality of life adjustment among nursing students, it is necessary to increase their mattering.