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논문검색

Original Article

브린졸라미드 복합제의 개방각 녹내장 또는 고안압증에 대한 효과 및 안전성 검증 : 체계적 문헌 고찰 및 메타분석 연구

원문정보

Effectiveness and Safety Verification of Brinzolamide Combination Therapy on Primary Open-angle Glaucoma or Ocular Hypertension : A Systematic Review and Meta-analysis Study

김진아, 이희영

피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Background: The treatment of primary open-angle glaucoma (POAG) or ocular hypertension (OHT) for intraocular pressure (IOP) reduction is recommended to proceed with the use of the compound. Therefore, this study aimed to evaluate the efficacy and safety of brinzolamide combination therapy on POAG and OHT following the subgroup analysis among types of brinzolamide combined medications. Methods: By June 2019, PubMed, EMBASE and Cochrane Library were searched to find a study that met our inclusion criteria. Based on randomized control trials (RCTs), we collected studies that tested the brinzolamide combination therapy in POAG and OHT patients, and analyzed the literature identified by the results of the study on IOP reduction and adverse reactions. Results: A total of 13 literature was collected to conduct an analysis including 2,197 patients. The intervention included brinzolamide combination therapies, combined with timolol, brimonidine, PGA or combined with both brimonidine and PGA. The analysis showed significant decreasing tendency for values at morning and end treatment per day in the use of brinzolamide combination therapy in the absolute IOP change (mean difference (MD) −1.41; 95% CI −1.92, −0.90; p<0.001 vs. MD −1.46; 95% CI −2.03, −0.89; p<0.00001, respectively). We could see higher adverse reactions in the brinzolamide combination group using intervention (odds ratio 1.43; 95% CI 1.20, 1.71; p<0.0001). Conclusion: Regarding IOP reduction in POAG and OHT patients, brinzolamide combination therapy is more effective but less safe than control treatment, which diverse among types of combined medications. Thus, more individualized therapy should be applied in real-world practice.

목차

ABSTRACT
연구 방법
문헌 검색
문헌 선택
비뚤림 평가
자료의 통합 및 분석
연구 결과
문헌 선택 결과
체계적 문헌고찰 대상문헌들의 개별적 특성
유효성 분석
안전성 분석
선택 문헌의 비뚤림 위험 평가
고찰
결론
참고문헌

저자정보

  • 김진아 Jin A Kim. 충북대학교 약학대학, 식품의약품안전평가원 첨단의약품품질심사과
  • 이희영 Heeyoung Lee. 건양대학교 임상의약학과

참고문헌

자료제공 : 네이버학술정보

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