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Objectives: The purpose of this study was to investigate the relationship between distress and oral health of Generation Y amid the COVID-19 pandemic, and to improve their psychological and oral health. Methods: An online survey was conducted among 204 individuals (born between 1982 and 2000) who visited building M in area G. Results: The respondents had high distress related to depression, helplessness, and travel restrictions. The biggest oral health-related factor influencing overall distress was self-awareness of toothache. Conclusions: The results of this study are highly valuable as basic data for initiating psychological and mental recovery support programs to overcome COVID-19 distress for effective oral health-related policies.