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Purpose: The authors used a meta-analysis approach to investigate the effects of exercise on gender-specific triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) in obese adolescents. Methods: This study is a systematic review and meta-analysis study to confirm the effect of exercise intervention according to gender for obese adolescents. PICO were obese a adolescents, exercise intervention, comparative intervention (control and general group),TG and HDL-C. Results: The group of obese male adolescents showed a statistically significant decrease of 51.72 in TG (n=175, MD=-51.72; 95% CI -52.44 to -51.00).There was a statistically significant increase of 4.44 in HDL-C (n=175, MD=4.44; 95% CI 3.79 to 5.10) in the group of obese male adolescents. Conclusion: Triglyceride and high-density lipoprotein cholesterol were analyzed to determine the effect of exercise interventions in obese adolescents according to gender differences. The results of this study can be used as basic data for the design of future exercise intervention studies, subjects, exercise methods, and intervention periods.