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Purpose: The purpose of this study is to find out effect on the metabolic syndrome of security workers, and to provide basic data in preparing health policies for security workers. Methods: We analyzed the results of a special health checkup of 373 workers who received spicial medical checkups for night work at the University Hospital in Seoul, 2017 Results: As a result of the analysis, it was found that the isolation work alone had an effect on the prevalence of metabolic syndrome. Conclusion: Given that the isolation of night shift security workers affects the prevalence of the target syndrome. Korea also needs to limit isolation of night shift workers in preparing health policies and propose working conditions for two to one. At the same time, We suggest that preventive programs for safety accidents and health care should be prepared to cope with the work hours of isolation at night.