earticle

영어

Seized pink capsule containing white powder was extracted with methanol using ultra-sonication method. Gas chromatography-Mass spectrometry(GC-MS) was used for identification of this sample, and putative 2-aminopropyl-2,3- dihydrobenzofuran(APDB) and caffeine were detected. APDBs is a central nervous system(CNS) stimulant classified as phenethylamines. It is an analogue of 3,4-methylenedioxyamphetamine(MDA) where the heterocyclic 4-position oxygen from the 3,4-methylenedioxy ring has been replaced with a methylene bridge. To elucidate exact chemical structures of target compound, the methanol extract was isolated with preparative high performance liquid chromatography(HPLC) to separate the target compound from caffeine. Then, target compound was analyzed with one-dimensional(1D-) and two-dimensional(2D)-nuclear magnetic resonance(NMR). The 1H-NMR spectra presented 15 proton signals and the 13C-NMR spectra exhibited 11 carbon signals. All the protons and carbons were assigned by their couplings and correlations observed in 1H-13C Hetero nuclear Multiple Bond Correlation(HMBC) and 1H-13C Hetero nuclear Single Quantum Coherence(HSQC) spectra. From all of analysis data, target compound was identified as 6-APDB and 6-APDB was first founded in our country.