earticle

논문검색

Original Article

Treadmill exercise improves spatial learning ability by increasing cell proliferation in offspring born to maternal rats receiving stress during pregnancy

원문정보

Tae-Woon Kim, Young Jun Ko, Ki-Hyok Youn, Boo-Geun Hwang, Hyun-Seok Bang, Sam-Jun Lee

한국운동재활학회 JER Vol.17 No.2 2021.04 pp.88-95
피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

Prenatal stress causes learning deficits by inhibiting neurogenesis in the hippocampus. We studied the effects of maternal treadmill running or offspring treadmill running on the spatial learning ability of adoles-cent offspring rats or adult offspring rats born to maternal rats that re-ceived stress during pregnancy. For this study, spatial learning ability was measured by radial 8-arm maze task. Immunohistochemistry for 5-bromo-2’-deoxyuridine and Western blot for brain-derived neuro-trophic factor (BDNF), tyrosine kinase B (TrkB), Bcl-2-associated X pro-tein (Bax), and B-cell lymphoma 2 (Bcl-2) were also conducted. Stress was induced by exposing pregnant rats to hound in an enclosed room. Maternal treadmill running or treadmill running of offspring improved spatial learning ability of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring increased hippocampal cell proliferation of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or tread-mill running of offspring increased BDNF and TrkB expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Maternal treadmill running or treadmill running of offspring inhibited Bax expression and increased Bcl-2 expression in the hippocampus of adolescent and adult offspring rats born to maternal rats receiving stress during pregnancy. Mother’s exercise during pregnancy or child’s exercise after childbirth can im-prove the spatial learning ability deteriorated due to stress during preg-nancy.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Adolescent and adult rats
Inducing stress in pregnant rats
Exercise protocol
Radial 8-arm maze task
Tissue preparation
Immunohistochemistry for BrdU
Western blot for BDNF, TrkB, Bax, and Bcl-2
Data analysis
RESULTS
Spatial learning ability
Cell proliferation
BDNF and TrkB expression
Bax and Bcl-2 expression
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

저자정보

  • Tae-Woon Kim Department of Human Health Care, Gyeongsang National University, Jinju, Korea
  • Young Jun Ko Major in Sport Service Practice, College of Welfare Convergence, Kangnam University, Yongin, Korea
  • Ki-Hyok Youn Department of Social Welfare, College of Health, Welfare and Education, Tongmyong University, Busan, Korea
  • Boo-Geun Hwang Department of Sport Rehabilitation, College of Health, Welfare and Education, Tongmyong University, Busan, Korea
  • Hyun-Seok Bang Department of Sport Rehabilitation, College of Health, Welfare and Education, Tongmyong University, Busan, Korea
  • Sam-Jun Lee Department of Sport Rehabilitation, College of Health, Welfare and Education, Tongmyong University, Busan, Korea

참고문헌

자료제공 : 네이버학술정보

    ※ 기관로그인 시 무료 이용이 가능합니다.

    • 4,000원

    0개의 논문이 장바구니에 담겼습니다.