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논문검색

Original Article

Resistance exercise improves short-term memory through inactivation of NF-κB pathway in mice with Parkinson disease

원문정보

Sang-Hoon Kim, Young Jun Ko, Seung-Soo Baek

한국운동재활학회 JER Vol.17 No.2 2021.04 pp.81-87
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초록

영어

Dysfunctions of Parkinson disease (PD) are classified into motor dys-function, autonomic nervous system dysfunction, and nonmotor dys-function, and clinical symptoms such as muscle stiffness, tremors, speech disorders, balance disorders, and slow movements appear. Resistance exercise is a main compartment of exercise programs for PD patient. The effect of resistant exercise on short-term memory in PD mice was studied in relation to the activation of nuclear factor (NF)-κB pathway. PD was induced by subcutaneous injection of 1-methyl-4- phenyl-1,2,3,6-tetrahydropyridine. For resistance exercise, mice per-formed ladder climbing 5 days per week for 5 weeks. Step-down avoid-ance test for short-term memory, enzyme-linked immunoassay for tu-mor necrosis factor (TNF)-α, interleukin (IL)-6, and IL-1β, Western bot for NF-κB, NF-κB inhibitor (IκB)-α, B-cell lymphoma 2 (Bcl-2)-associated X protein (Bax), and Bcl-2, and immunohistochemistry for cleaved caspase-3 were done. Latency time was shortened, TNF-α, IL-6, and IL-1β concentration was increased, NF-κB expression and IκB-α phos-phorylation were increased, cleaved caspase-3 and Bax expression was enhanced, and Bcl-2 expression was suppressed by PD induction. Latency time was lengthened, TNF-α, IL-6, and IL-1β concentration was decreased, NF-κB expression and IκB-α phosphorylation were sup-pressed, cleaved caspase-3 and Bax expression was decreased, and Bcl-2 expression was increased in PD mice by resistance exercise or levodopa treatment. Resistance exercise improved short-term memory by inhibiting secretion of proinflammatory cytokines and apoptosis through inactivation of NF-κB. These effects of resistance exercise were similar to levodopa treatment.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Experimental animals
Induction of PD
Resistance exercise and drug treatment
Step-down avoidance test
Tissue preparation
Proinflammatory cytokines
Western blotting
Immunohistochemistry
Data analysis
RESULTS
Latency time
Concentration of TNF-α, IL-6, and IL-1β
NF-κB expression and IκB-α phosphorylation
Cleaved caspase-3, Bax, and Bcl-2 expression
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

저자정보

  • Sang-Hoon Kim Department of Sport & Health Sciences, College of Art & Culture, Sangmyung University, Seoul, Korea, Department of Physiology, College of Medicine, Kyung Hee University, Seoul, Korea
  • Young Jun Ko Major in Sport Service Practice, College of Welfare Convergence, Kangnam University, Youngin, Korea
  • Seung-Soo Baek Department of Sport & Health Sciences, College of Art & Culture, Sangmyung University, Seoul, Korea

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