원문정보
초록
영어
The presence of apolipoprotein (Apo) E4 is a genetic risk factor in cog-nitive impairment. Physical exercise contributes to slowing cognitive impairment in older adults, but little is known about the influence of ex-ercise on ApoE4 carriers and noncarriers. The objective of systematic review is to study the role of physical exercise in older adults’ ApoE4 carriers and noncarriers. A systematic literature search was carried out in five international databases: PubMed, Web of Science, PeDro, Scopus, and SPORTDiscus. A total of nine randomized controlled trials were included with a sample size of 2,025 subjects (901 ApoE4 carriers). The exercise reported a significant improvement on cognitive perfor-mance in older adults’ ApoE4 noncarriers (standardized mean differ-ence [SMD]=0.653; 95% confidence interval [CI], 0.29–1.00; chi2=35.36; degrees of freedom [df ]=7; P<0.0001; l 2=80%). It was also reported that a total program duration greater than 50 sessions generated differ-ent and significant effects on cognitive performance in older adults’ ApoE4 noncarriers (SMD=0.878; 95% CI, 0.14–1.61; chi2=31.82; df=3; P<0.0001; l 2=91%). The results reported that high intensity generated a differential effect on cognitive performance in older adults’ ApoE4 carri-ers versus noncarriers (SMD=0.963; 95% CI, 0.25–1.67; chi2=18.11; df=3; P<0.0004; l 2=83%). The effect of physical exercise on cognitive perfor-mance in older adults is conditioned by the presence or not of ApoE4.
목차
INTRODUCTION
MATERIALS AND METHODS
Search strategy
Criteria for inclusion
Criteria for exclusion
Data extraction
Risk of bias
Data analysis
Meta-analysis
Subgroup analysis
RESULTS
Study selection
Description of studies
Participants’ characteristics
Intervention characteristics
Meta-analysis
DISCUSSION
CONCLUSIONS
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES