earticle

논문검색

Review Article

Effect of physical exercise on cognitive function in older adults’ carriers versus noncarriers of apolipoprotein E4 : systematic review and meta-analysis

원문정보

José María Cancela-Carral, Adriana López-Rodríguez, Irimia Mollinedo-Cardalda

한국운동재활학회 JER Vol.17 No.2 2021.04 pp.69-80
피인용수 : 0(자료제공 : 네이버학술정보)

초록

영어

The presence of apolipoprotein (Apo) E4 is a genetic risk factor in cog-nitive impairment. Physical exercise contributes to slowing cognitive impairment in older adults, but little is known about the influence of ex-ercise on ApoE4 carriers and noncarriers. The objective of systematic review is to study the role of physical exercise in older adults’ ApoE4 carriers and noncarriers. A systematic literature search was carried out in five international databases: PubMed, Web of Science, PeDro, Scopus, and SPORTDiscus. A total of nine randomized controlled trials were included with a sample size of 2,025 subjects (901 ApoE4 carriers). The exercise reported a significant improvement on cognitive perfor-mance in older adults’ ApoE4 noncarriers (standardized mean differ-ence [SMD]=0.653; 95% confidence interval [CI], 0.29–1.00; chi2=35.36; degrees of freedom [df ]=7; P<0.0001; l 2=80%). It was also reported that a total program duration greater than 50 sessions generated differ-ent and significant effects on cognitive performance in older adults’ ApoE4 noncarriers (SMD=0.878; 95% CI, 0.14–1.61; chi2=31.82; df=3; P<0.0001; l 2=91%). The results reported that high intensity generated a differential effect on cognitive performance in older adults’ ApoE4 carri-ers versus noncarriers (SMD=0.963; 95% CI, 0.25–1.67; chi2=18.11; df=3; P<0.0004; l 2=83%). The effect of physical exercise on cognitive perfor-mance in older adults is conditioned by the presence or not of ApoE4.

목차

Abstract
INTRODUCTION
MATERIALS AND METHODS
Search strategy
Criteria for inclusion
Criteria for exclusion
Data extraction
Risk of bias
Data analysis
Meta-analysis
Subgroup analysis
RESULTS
Study selection
Description of studies
Participants’ characteristics
Intervention characteristics
Meta-analysis
DISCUSSION
CONCLUSIONS
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES

저자정보

  • José María Cancela-Carral HealthyFit Research Group, University of Vigo, Pontevedra, Spain, Galicia Sur Health Research Institute (IIS Galicia Sur), Sergas-UVIGO, Pontevedra, Spain Faculty of Education and Sports Science, University of Vigo, Pontevedra, Spain
  • Adriana López-Rodríguez Galicia Sur Health Research Institute (IIS Galicia Sur), Sergas-UVIGO, Pontevedra, Spain, Faculty of Education and Sports Science, University of Vigo, Pontevedra, Spain
  • Irimia Mollinedo-Cardalda Galicia Sur Health Research Institute (IIS Galicia Sur), Sergas-UVIGO, Pontevedra, Spain, Faculty of Physiotherapy, University of Vigo, Pontevedra, Spain

참고문헌

자료제공 : 네이버학술정보

    ※ 기관로그인 시 무료 이용이 가능합니다.

    • 4,300원

    0개의 논문이 장바구니에 담겼습니다.