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Abstracts for poster Presentation

O-GlcNAcylation of XIAP reduces OGT via proteasomal degradation and inhibits cell growth and invasion in colon cancer cell

원문정보

Hyeon Gyu Seo, Han Byeol Kim, Tae Hyun kweon, Jingu Kang, SeongJin Son, Jinju Song, Won Ho Yang, Jin Won Cho

한국당과학회 한국당과학회 학술대회 2020 한국당과학회 연례학술대회(온라인) 2021.01 pp.38-38
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초록

영어

XIAP (X-linked inhibitor of apoptosis) is an inhibitor of apoptotic cell death. It consists of a RING domain and functions as an E3 ligase. In this study, we identify OGT (O-linked N-acetylglucosamine (O-GlcNAc) Transferase) as a substrate of XIAP. In addition, we show that OGT catalyses the O-GlcNAcylation XIAP at serine 406, and that this modification in turn regulates the E3 ligase activity of XIAP towards OGT. Substitution of XIAP serine 406 by alanine decreased its E3 ligase activity toward OGT but not toward other substrates. Stable overexpression of XIAP in HCT116 human colorectal carcinoma cells decreased OGT protein levels and inhibited cancer cell growth and invasion. These results suggest that O-GlcNAcylation of XIAP is required for its E3 ligase activity toward OGT, which leads to OGT degradation and ultimately the inhibition of cancer cell growth.

저자정보

  • Hyeon Gyu Seo Glycosylation Network Research Center, Yonsei University
  • Han Byeol Kim Glycosylation Network Research Center, Yonsei University
  • Tae Hyun kweon Glycosylation Network Research Center, Yonsei University, Interdisiplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University
  • Jingu Kang Glycosylation Network Research Center, Yonsei University, Interdisiplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University
  • SeongJin Son Glycosylation Network Research Center, Yonsei University, Interdisiplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University
  • Jinju Song Glycosylation Network Research Center, Yonsei University, Interdisiplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University
  • Won Ho Yang Glycosylation Network Research Center, Yonsei University, Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University
  • Jin Won Cho Glycosylation Network Research Center, Yonsei University, Department of Systems Biology, College of Life Science and Biotechnology, Yonsei University, Interdisiplinary Program of Integrated OMICS for Biomedical Science, Graduate School, Yonsei University,

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