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Objectives: The purpose of this study was to identify the factors influencing university students’quality of life related to oral health. Methods: Data from 176 students were collected using a structured questionnaire. The data were analyzed using an independent t-test, one-way ANOVA and multiple regression with the SPSS 25.0 program. Results: There were significant differences in oral health status according to sex(t=-2.42, p=.034), grade(F=4.30, p=.006), snack intake(t=-2.51, p=.013), smoking(t=2.41, p=.017), and disease(t=2.49, p=.014), and oral health behavior was significantly different according to major(t=3.04, p=.003), smoking(t=-3.76, p<.001), and last oral health education period(F=9.10, p<.001). As a result of multiple regression analysis, oral health status was found to be a significant related factor in oral health-related quality of life(β=.409, p<.001). Conclusions: Oral health management of university students is necessary, and active support and intervention from the school and the government should be made in the development and implementation of the oral health education program for university students.