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Purpose: This study was conducted to identify the relationship between academic achievement, depression, anxiety, and grit in nursing students. Methods: Data were collected through structured questionnaires, and the study subjects were 93 students who agreed to participate in the study. The collected data were analyzed, using SPSS 25.0, by descriptive analysis, independent t-test, one-way ANOVA and pearson correlation analysis. Results: In this study, there was a significant positive correlation between depression and anxiety (r=.616, p<.001) and negative correlations between depression and grit (r=-.379, p<.001) and between depression and academic achievement (r=-.230, p=.026). Grit showed a significant positive correlation with academic achievement (r=.407, p<.001). Conclusion: According to these results, it is necessary to develop programs that can reduce depression and anxiety and increase grit in order to improve the academic achievement of nursing students.