earticle

영어

Hypochlorous acid water can promote pruritus as an adverse effect under certain conditions, which should be taken into account to ensure safety. In recent days, Mineral Supplement Hypochlorous Acid Water (MS-HOCl) has received massive attention in research as a new-concept cleansing agent due to its high sterilizing properties, easy accessibility, and safety aspects. This present study was conducted to evaluate the drinking effects of MS-HOCl treatment of the Helicobacter pylori (H. pylori )-infected C57BL/6 mouse model to verify the safety effects. The experimental mice were divided into 3 groups: NC (Purified water + no infection), PW (Purified water + H. pylori infection), and MS-HOCL (MS-HOCl + H. pylori infection). Water was supplied through water bottle for mouse for 4 weeks, and changed once a day. We measured the bodyweight, and total WBC and its differential counts such as lymphocytes, monocytes, neutrophil, eosinophil and basophil. Besides that, we also tested biochemical markers such as reactive oxygen species (ROS), nitric oxide (NO), glutathione peroxides (GPx), and calcium activity in both serum and stomach lysate samples. Our results showed that daily oral administration of MS-HOCl water for 4 wk did not show any abnormal findings about hematological and biochemical parameters such as ROS, NO, GPx, and calcium activity in both serum and stomach lysate. There were no significant differences in bodyweight between the three groups. Overall, our results showed no negative effects of drinking MS-HOCl in the H. pylori -infected C57BL/6 mice model. However, more controlled studies are needed to determine the safety of drinking MS-HOCl.