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Purpose: This study aimed to determine the mediating effect of emotional intelligence on the relationship between the social support and job satisfaction of general hospital nurses. Methods: The data of 197 nurses in general hospitals located in three different cities were collected for analysis. Collected data were analyzed using the t-test, ANOVA, Scheffé test, Pearson's correlation coefficients, and hierarchical multiple regression with SPSS/WIN 23.0. Results: The social support of the subjects showed positive correlations with job satisfaction (r=.56, p<.001) and emotional intelligence (r=.42, p<.001). Emotional intelligence and job satisfaction were positively correlated (r=.54, p<.001). Emotional intelligence was found to perform the partial mediation in the relationship between social support and job satisfaction. Conclusion: To improve job satisfaction, an organizational culture which enhances social support may be required as an intervention strategy, and programs should be developed to induce positive emotional intelligence.