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Purpose: Despite the importance of mental health-related quality of life among workers, its comprehensive understanding is lacking. This study aimed to identify influencing factors regarding mental health-related quality of life through a comprehensive literature review. Methods: The integrative review method of Whittemore and Knaf was used. Data search was conducted on papers published before September 2020, and RISS, NDSL, and KISS were used for the search. Results: Fourteen studies were selected for analysis. Five factors affecting the mental health-related quality of life of workers were found. Mental and physical health status, job stress, working environment, health behaviors, and other personal and socio-economic characteristics were significant influencing factors. Conclusion: Findings from the review suggest the necessity of developing a customized intervention program to improve the mental health-related quality of life of workers.