earticle

영어

This study was conducted to confirm the component and efficacy evaluation of Buxus Koreana by different part. Leaf, stem, root, and fruit were extracted with 70% ethanol, and the contents of polyphenols and flavonoids were analyzed, and the efficacy against anti-inflammatory, moisturizing and wrinkles were confirmed. The contents of polyphenols and flavonoids of B. Koreana were the highest in fruit extracts at 77.32 and 51.91 mg/g, respectively. As a result of confirming the NO production inhibitory effect, the root extracts showed an inhibitory effect of 29.6%, and iNOS significantly decreased as the concentration of the extracts increased compared to the LPS treatment group. As a result of checking the mRNA expression level of MMP1, it was found to be effective in the root and stem extracts. Through the efficacy evaluation of B. Koreana the possibility of use as a cosmetic material was confirmed.

한국어

본 연구는 회양목의 부위별 성분과 효능평가를 확인하기 위해 수행되었다. 잎, 줄기, 뿌리, 열매를 70% 에탄올로 추출하여 폴리페놀과 플라보노이드의 함량을 분석하였으며 항염, 보습 및 주름에 대한 효능을 확인하였 다. 회양목의 부위별 폴리페놀과 플라보노이드 함량은 열매 추출물에서 각각 77.32, 51.91 mg/g으로 가장 높게 나타났다. NO 생성 억제 효과를 확인한 결과, 뿌리 추출물에서 29.6%의 저해 효과를 나타냈으며, iNOS는 LPS 처리군과 비교하였을 때 추출물의 농도가 증가함에 따라 유의적으로 감소하였다. MMP1의 mRNA 발현 수준을 확인한 결과, 뿌리와 줄기에서 효과가 있는 것으로 나타났다. 회양목에 대한 효능평가를 통해 화장품 소재로서 활 용 가능성을 확인하였다.