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The aim of this study was to examine whether a high-volume compared to low-volume resistance exercise session acutely impairs lung func-tion. Fourteen males (age 23.8±6.5 years) with resistance training expe-rience participated in this study. Participants completed two resistance training protocols (high- and low-volume) and a control session (no ex-ercise) with the sequence randomised. High- and low-volume sessions involved 5 sets (5-SETS) and 2 sets (2-SETS), respectively of 10 repeti-tions at 65% one-repetition maximum for each exercise (bench press, squat, seated shoulder press, and deadlift) with 90-sec recovery be-tween sets. Lung function was evaulated pre- and postsession and re-spiratory gases were measured during the recovery between sets of exercises. An increase in the ratio of forced expiratory volume in 1 sec (FEV1) to forced vital capacity was found following the 5-SETS com-pared to 2-SETS (P=0.033). There was a significant reduction in inspira-tory capacity following 5-SETS compared to control session (P=0.049). No other lung function parameter was affected postsession. During training sessions, the squat and deadlift required greater ventilatory de-mands compared to the bench press and shoulder press (P<0.001). Across most exercises during 5-SETS compared to 2-SETS, there was a lower end-tidal CO2 partial pressure. Across most exercises during 5-SETS compared to 2-SETS there was a lower end-tidal CO2 partial pressure (PETCO2) (P≤0.013), although there were no other differences in physiological responses between the sessions. The findings tend to suggest that the ventilatory and respiratory muscle demands of a stren-uous resistance exercise session are not great enough to acutely im-pair indices of lung function.