원문정보
초록
영어
This study aimed to determine the effect of pool gait exercise using fibromyalgia- induced model mice. The sensory threshold, locomotive behavior, electrocardiogram, and onset time after the gait test in shallow water using male C57BL/6J mice (weight, 30–35 g; n= 21) were investigated. To induce fibromyalgia in model mice, reserpine was injected intraperitoneally into wild-type mice once a day for 3 days. Subsequently, the fibromyalgia-induced model mice were randomly classified into two groups as follows: the control group (n= 11) and the pool gait group (n= 10). The mice in the pool gait group walked in the same cage containing shallow warm water 5 times per week. Both groups underwent sensory thresholds and video recordings to determine locomotive behaviors weekly. Further, both heart rate and video recordings for observation of a recovery after the gait test in shallow water were undertaken (control group; n= 5, pool gait group; n= 5). The pool gait did not affect sensory thresholds and locomotive behavior; however, in the pool gait group, both the recovery after the test, such as onset time and gait distance, were considerably better than those of the control group. Furthermore, changes in heart rate and heart rate irregularity after the test were more apparent in the control group than in the pool gait group. The free gait in a shallow pool accelerated recovery after exercise, unlike the sensory threshold.
목차
INTRODUCTION
MATERIALS AND METHODS
Animals
Reserpine-injected FM model mice
Two kinds of therapeutic gait exercises for the FM-induced model mice
Measurement of the sensory threshold with electrical- and heat-stimulation
Weekly evaluation of locomotive behavior during the gait exercises
Behavior evaluation during and after the gait exercise in the shallow water
Measurement of electrocardiogram before and after the gait exercise in shallow water
Statistical analysis
RESULTS
Modulation of sensory thresholds and locomotive behavior in FM-induced model mice
Change of locomotive behavior in FM model mice
Comparison of sensory thresholds with or without free gait in shallow warm water
Comparison of locomotive behavior with or without free gait in shallow warm water
Comparison of motor recovery with or without free gait in shallow warm water
Comparison of the cardiac function with or without the free gait in the water
DISCUSSION
Mechanisms of pool gait-induced motor recovery
Mechanisms due to which pool gait-induced motor recovery did not accompany improvements in the sensory threshold
Study limitations and clinical application
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES