원문정보
초록
영어
Maternal obesity is known to increase the likelihood of offspring be-coming obese, high blood pressure, and other metabolic disorders. Af-ter inducing obesity, the effect of treadmill exercise in maternal rats during pregnancy on short-term memory was investigated in relation to neurogenesis in rat pups. Short-term memory was declined in rat pups born to obese maternal rats, and treadmill running during pregnancy al-leviated short-term memory impairment in rat pups born to obese ma-ternal rats. The number of doublecortin (DCX)-positive and 5-bro-mo-2′-deoxyuridine (BrdU)-positive cells in the hippocampal dentate gyrus was decreased in rat pups born to obese maternal rats. Treadmill running during pregnancy increased the number of DCX-positive and BrdU-positive cells in rat pups born to obese maternal rats. Expression of brain-derived neurotrophic factor (BDNF) and tyrosine kinase B (TrkB) in the hippocampus was decreased in the rat pups born to obese maternal rats. Treadmill running during pregnancy increased the ex-pressions of BDNF and TrkB in rat pups born to obese maternal rats. Enhancing effect of short-term memory by treadmill exercise may be due to increased neurogenesis through activation of the BDNF-TrkB signaling pathway by treadmill exercise.
목차
INTRODUCTION
MATERIALS AND METHODS
Animals
Treadmill exercise protocol and BrdU injection
Step-down avoidance task
Tissue preparation
Immunohistochemistry for DCX
Immunohistochemistry for BrdU
Western blot analysis
Data analysis
RESULTS
Short-term memory
Number of DCX-positive cells
Number of BrdU-positive cells
BDNF and TrkB expression
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES