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Objectives: This study aimed to elucidate the relationship between nurses’ technostress and organizational performance (job satisfaction, organizational commitment, productivity, and turnover intention) and enhance the conceptual and empirical understanding of technostress. Methods: The study included a questionnaire survey of 250 nurses at a university hospital located in C city. The nurses had more than six months of experience in clinical practices at the time of data collection, and they gave their prior consent to participate in this study. Overall, 211 questionnaires were analyzed using SPSS Statistics 24.0 and AMOS 21.0. Results: The participants’ technostress was found to have a direct effect on their job satisfaction, which, in turn, directly influenced their organizational commitment. Moreover, technostress was found to directly affect their productivity. While job satisfaction did not have a direct effect on the nurses’ turnover intention, there was an indirect influence through organizational commitment. The turnover intention was found to be directly influenced by organizational commitment. Finally, productivity had no direct effect on their turnover intention. Conclusions: This study provides basic information that would help nurse managers to improve the performance outcomes of the nursing organization and manage the establishment more efficiently.