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Purpose: This study analyzes the self-efficacy and CAD/CAM practice of dental technology students with the aim of providing data that will be useful for improving CAD/CAM education. Methods: A questionnaire survey on self-efficacy and CAD/CAM practice was given to students who participated in face-to-face classes in the Department of Dental Technology at a college in Daegu and Gyeongsangnam-do. The survey period was two weeks long (June 15, 2020 to July 2, 2020), and 84 students completed the questionnaire. Results: The higher the self-efficacy, the fewer difficulties or mistakes students made in CAD/CAM practice. The most difficult parts of the scanning process were the top and bottom arc operation and the bite match arc insertion. The most difficult part of the design work was the use of (multiple) tools. The difference between the degree of difficulty and the degree of mistakes during the practical course was shown as the margin line setting in the design work. Setting the margin line was not difficult, but the degree of mistakes was nonetheless high. In the CAM process, height control was the most difficult part, but the degree of mistakes did not differ according to students’ self-efficacy. Conclusion: Given that higher self-efficacy correlated with fewer difficulties or mistakes in CAD/CAM practice, students should be encouraged to enhance their self-efficacy. This may be done by improving their satisfaction with their major course of study, forming friendly relations with their colleagues, and increasing the ratio of performance rather than observation in CAD/CAM practice.