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Purpose: The aim of the research was to define the effects of lifestyle habits, smartphone addiction, and mental health on irritable bowel syndrome in college students Methods: The data was collected through convenience sampling of 185 college students. To draw conclusions from the data, we used statistical analysis of independent t-test, x2 test, Fisher’s exact test, and multiple logistic regression using SPSS/WIN 24.0. Results: There were significant differences in gender, grade, major, mental health, and smartphone addiction according to the presence of irritable bowel syndrome. Variables identified as influencing factors were gender (OR=4.03, CI: 1.42~11.49) and mental health (OR=1.05, CI: 1.01~1.08). Conclusion: In order to alleviate and improve the symptoms of irritable bowel syndrome, it is necessary to assess and continuously manage mental health, such as stress, anxiety and depression of college students, which are the factors that could be intervened.