원문정보
초록
영어
The cabbage extract of the research does not show cytotoxicity, and thus can be used safely. In an experiment performed on an animal model with liver injury induced by a drug (APAP), it could be seen that the cabbage extract exhibited the effects of protecting liver and improving liver function by effectively reducing AST and ALT which are liver injury markers, indicating that the cabbage extract is effective as a pharmaceutical composition for preventing or treating liver disease. In particular, the cabbage extract was effective in treating inflammation of the liver by reducing the expression of the inflammatory mediators iNOS and COX-2 and the proinflammatory cytokine IL-1β, which are involved in acute inflammatory reactions accompanying liver injury. In the research, an extract of cabbage heat-treated at a temperature of 100 to 150°C had a better liver function-improving effect or anti-inflammatory effect than an extract of raw cabbage.
목차
1. Introduction
2. Experiment Materials and Methods
2.1 Preparation of Heat-Treated Cabbage Extract(HCE)
2.2 Evaluation of Cytotoxicity
2.3 Evaluation of Hepatoprotective Effect of a Cabbage Extract
2.4 Evaluation of Anti-Inflammatory Effect of Cabbage Extract
2.5 Statistical analysis
3. Result and Discussion
3.1 Cell viability of a cabbage extract
3.2 Liver function (ALT and AST) improving activity of a cabbage extract
3.3 Evaluation of Hematoxylin & Eosin (H&E)
3.4 Evaluation of Anti-Inflammatory of Cabbage Extract
4. Conclusion
References