원문정보
초록
영어
Imazosulfuron is globally considered as a relatively safe herbicide that controls plant growth by interfering with amino acid synthesis. It is stable, persists in the soil, and has low toxicity; however, studies about the toxic effects of imazosulfuron on non-targeted aquatic vertebrates are scarce. In this study, imazosulfuron was able to induce acute lethality on zebrafish embryos within 48 h. Imazosulfuron also had adverse effects on heartbeats and induced abnormal development with pericardial edema and scoliosis. Moreover, apoptosis and oxidative stress were increased by imazosulfuron in a dose-dependent manner. Thus, all our results showed that imazosulfuron has toxic effects on zebrafish embryogenesis.
목차
INTRODUCTION
MATERIALS AND METHODS
Zebrafish model and morphology
Detection of apoptotic cells in zebrafish
ROS production in zebrafish
Statistical analysis
RESULTS
Anti-developmental effects of imazosulfuron on zebrafish embryos
Lethal effects of imazosulfuron on zebrafish embryos
Oxidative stress mediated apoptosis on zebrafish embryos
DISCUSSION
CONCLUSION
CONFLICTS OF INTEREST
ACKNOWLEDGEMENTS
AUTHOR CONTRIBUTIONS
AUTHOR’S POSITION AND ORCID NO.
REFERENCES