earticle

영어

This study was performed to demonstrate the effect of schizophrenia and aerobic exercise training on agiogenic factors in skeletal muscle of rats. Twenty one SD-rats were randomly assigned to control (CON), schizophrenia (SCH), and schizophrenia+aerobic exercise training (SCH+AET) groups. SCH and SCH+AET groups were treated with MK-801 for 2 weeks and only SCH+AET group ran on a rodent treadmill for 30min at speed of 22m/min for 4 weeks (5d/w). The changes of NMDAR1, HIF-1α, VEGF, and FGF protein expression were analyzed by western blotting with soleus muscle. NMDA receptor and VEGF protein expressions were significantly lower in SCH than in CON group, however these were significantly higher in SCH+AET group. On the contrary, there were no differences between groups in HIF-1α and FGF protein expressions. These results suggest a possibility that induction of schizophrenia by MK-801 may occur decreased angiogenesis and regular aerobic exercise training could alleviate or improve it in skeletal muscle.