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Purpose: The purpose of this study is to identify the relationship between perceived smartphone addiction and physical and mental health among female college students. Methods: Data were collected using a questionnaire to measure perceived smartphone addiction and physical and mental health of 314 female students attending a college located in D city from April 9 to May, 31, 2019. The collected data were analyzed using descriptive statistics, x2 test, t-test and stepwise multiple regression with SPSS 18. Results: The respondents were classified into two groups, the perceived smartphone addiction group (29.3%) and the perceived smartphone non-addiction group (70.7%). Perceived smartphone addiction was significantly different according to daily smartphone usage time (p<.001), smartphone usage fee (p=.005), most satisfying thing about using smartphones (p=.006) and importance of smartphones in daily life (p<.001). The perceived smartphone addiction group had more physical health problems (p=.001) and more mental health problems (p<.001). The factors affecting physical health were perceived smartphone addiction and importance of smartphones in daily life, with 62% of explanatory power (F=10.15, p<.001). As for mental health, the affecting factors were also perceived smartphone addiction and importance of smartphones in daily life, with 87% of explanatory power (F=14.52, p<.001). Conclusion: It is important to raise awareness of smartphone addiction including its negative impact on physical and mental health, reduce smartphone usage time, and build offline social relationships.