원문정보
초록
영어
Social isolation during adolescence is associated with anxiety, depres-sion, and memory impairment. Exercise has been reported as a positive effect on brain function, especially hippocampus. The present study ex-amined the effect of swimming exercise on apoptosis, cell proliferation, and serotonin expression in social isolation rats during adolescence stage. Social isolation started at postnatal day 21 and continued for 6 weeks. The rats in the swimming group were forced to swim for 60 min once daily during 6 days per week for 6 consecutive weeks. The rats in the social isolation during adolescence showed anxiety, depression, short-term memory impairment. Social isolation facilitated apoptosis and inhibited cell proliferation and differentiation. Social isolation sup-pressed expression of serotonin, brain-derived neurotrophic factor, and tyrosine kinase B. Swimming exercise alleviated anxiety, depression, short-term impairment. Swimming exercise suppressed apoptosis, en-hanced neurogenesis, and increased serotonin expression. In our study, swimming exercise ameliorates mood disorder and memory impairment by enhancing neurogenesis and serotonin expression and inhibiting apoptosis in social isolation.
목차
INTRODUCTION
MATERIALS AND METHODS
Experiment animals
Swimming exercise protocol
Elevated plus-maze test
Forced swimming test
Step-through avoidance test
Tissue preparation
Immunohistochemistry for TPH, 5-HT in dorsal raphe
Immunohistochemistry for BrdU
Immunohistochemistry for DCX
TUNEL staining
Western blotting for BDNF, TrkB, Bax, and Bcl-2
Data analysis
RESULTS
Effect of swimming exercise on anxiety, depression, and short-term memory
Effect of swimming exercise on apoptosis in the hippocampus
Effect of swimming exercise on BDNF and TrkB expression in the hippocampus
Effect of swimming exercise on cell proliferation and differentiation in hippocampal dentate gyrus
Effect of exercise on TPH and 5-HT in the dorsal raphe
DISCUSSION
CONFLICT OF INTEREST
ACKNOWLEDGMENTS
REFERENCES