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Objectives: The aim of this study was to investigate cognitive function decline by socio-demographic and health-related characteristics (health behaviors and health status) using 5th Korean Longitudinal Study of Aging panel data. Methods: The subjects were 4,440 community-dwelling people aged over 57 years. The data were analyzed with descriptive statistics, frequency analysis, χ²-test, and binary logistic regression analysis using SPSS ver. 25.0. Results: The findings revealed that socio-demographic characteristics (gender, age, area of residence, educational level, marital status, number of children, number of grand-children) and health-related characteristics (smoking, drinking, regular exercise, weight category by body mass index, hypertension and diabetes mellitus) were factors that influenced cognitive function decline (p<.05). Conclusions: Cognitive function decline was closely related to health behaviors and disease types. Future studies must examine related constructs to accurately determine these relationships among various populations. The present study could be used as a tool for the development and implementation of health promotion and prevention strategies.