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This study was a quasi-experimental study with a single group pre-posttest design for evaluating the effects and meanings of a global health training program for nursing students. A mixed data collection method utilizing both qualitative and quantitative methods was applied. The qualitative method consisted of reflection journal entry analysis, while the quantitative study evaluated data collected from a self-reported questionnaire. After attending the program, cultural competencies of participants significantly increased than pre-test while global citizenship was not. Through an analysis of reflection journals written during the overseas training period, the meanings of experiences derived after the program were classified into five themes and 12 sub themes, which were, ‘improvement of global health leadership’, ‘experience of barriers in reality’, ‘improvement of nursing professional value’, ‘inspiration of a perspective on health equity’, and ‘internal growth’. The results indicate that global health training program evaluated in this study was meaningful; it provided students with opportunities to experience the nurse’s role in diverse global environments and attempted to measure the effects.