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Objectives: This study aimed to evaluate digital interventions on psychological well-being in patients with cancer through an integrated review. Methods: Fifteen studies were selected using PubMed, CINAHL, Scopus, DBpia, and RISS. The Scottish Intercollegiate Guidelines Network was used by two reviewers to evaluate independently the quality of the selected articles. Results: Digital interventions for improving psychological well-being in cancer patients were most often based on cognitive behavioral therapy alone or a combination of interventions with professionals and other patients. In addition, a number of interventions were established on internet-based mindfulness therapy. Conclusions: Providing cognitive behavioral intervention alone did not significantly improve the level of depression or anxiety of patients with cancer. Meanwhile, interventions, including cognitive behavior therapy and interactions with professionals and other patients, were found to reduce significantly the level of depression or anxiety in the experimental group.