earticle

영어

DNA profiles obtained from skeletal samples of Korean War victims are put into a database for random matching and kinship analysis to confirm the relationship between missing casualties and their alleged relatives. It has been reported that the problem of the possibility of erroneous match between unrelated people became significant especially with growth of the number of genotypes in A-STR database. To solve the problem related to high false positive rates, higher kinship index threshold is required. However, use of high kinship index threshold results in extremely high false negative rate. Therefore, the use of increased number of autosomal markers with minimal kinship index threshold is recommended. Highly effective massively parallel SNP genotyping platforms using microarray technology were developed and have been used in various human population studies. We adopted resequencing microarray platform to apply autosomal SNP markers to inference of relatedness between missing casualties and their alleged relatives. Autosomal SNP markers analyzed using resequencing microarray platform showed remarkably higher likelihood ratios than 23 autosomal STR markers in kinship analysis of first to third degree of relatedness. Our results demonstrate that autosomal SNP markers hold great promise for identification of missing casualties.