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Objective: The purpose of this qualitative study was to explore the experience of emergency department nurses regarding the care of patients with alcohol problems in order to identify their recognition and attitudes about alcohol problems and alcoholism prevention strategies suitable in emergency department settings. The study question is ‘What about emergency department nurses’ experience with alcohol problems. Methods: The participants included 10 female nurses who are currently working or have worked in emergency department for more than three years. Individual interviews were conducted for a minimum of 30 minutes to less than an hour, and the collected data was analyzed in accordance with the qualitative content analysis proposed by Elo and Kyngäs. Results: The results revealed 5 categories: ‘Recognition and attitude toward alcohol problem’, ‘Clues to aware alcohol problems’, ‘Medical and surgical problems related to alcohol’, ‘Barriers to practice of alcoholism prevention’and ‘Interventions to prevent alcoholism in emergency department’. We found that emergency department nurses had negative attitudes toward people with alcohol problems. And also they recognized that interventions to prevent alcoholism were outside the scope of emergency care practices. Conclusion: Emergency department nurses had the ability to identify patient with alcohol problems and a high recognition of the needs of preventive approaches to alcohol problems. The results can be used to develop the education program for emergency department nurses and guidelines for prevention of alcoholism.