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Purpose: This study aimed to identify factors affecting the intention to donate organs among high school students. Methods: Data were collected using a questionnaire to measure the knowledge, attitudes, and intention regarding organ donation among 382 high school students in three high schools in one city in December 2018. Data analysis using SPSS 20.0 included a chi-squared test, the Mann-Whitney U test and a logistic regression model. Results: 69.9% of the subjects responded they had intention to donate organs. The factors influencing their organ donation intention were interest in organ donation (odds ratio: OR=3.49, p<.001), knowing the meaning of brain death (OR=7.79, p<.001), acceptive attitude (OR=4.35, p<.001), and exclusive attitude (OR=0.34, p<.001). Conclusion: Organ donation intention is an important factor in the interest in, knowledge of, and positive attitude towards organ donation. High school students should be educated to improve their knowledge and positive attitude regarding organ donation to increase their intention to donate organs.